Lin Zhao

The paper uses single-cell multiome data to identify QTLs regulating gene expression and chromatin accessibility during cellular senescence, revealing new causal variants and regulatory mechanisms.

This study identifies HSF1 as a mechanically sensitive regulator of left-right symmetry breaking in zebrafish embryos through nodal flow-induced gene expression asymmetry.

The paper identifies causal regulatory elements in complex genetic loci using CRISPR perturbations and shows that many causal variants lack classical epigenetic markers.