CCN1 forms a complex with GPC4 and heparin to fine-tune signaling activities for embryonic cortical neural stem cell maintenance
Jiangli Zheng, Shao-Jun Qi, Huan Wu, Jun Wu, Guo Chen, Huanhuan Joyce Wang, Han Pan, Ji Li, Cuiqin Cheng, Ke Tang, Lester F. Lau, Qin Shen
The paper shows CCN1 interacts with GPC4 and heparin to regulate NSC maintenance via the Shh pathway in embryonic cortical development.
bioRxiv · May 16, 2025 · PreprintDevelopmental Biology