In silico study of selected alkaloids as dual inhibitors of β and γ-Secretases for Alzheimer's disease
Isreal Ayobami Onifade, Haruna Isiyaku Umar, Abdullahi Tunde Aborode, Aeshah A. Awaji, Ifeoluwapo Deborah Jegede, Bunmi Helen Adeleye, Dorcas Oladayo Fatoba, Ridwan Opeyemi Bello, Sodiq Fakorede, Nike Jesutofunmi Idowu
This study identifies four alkaloids as potential dual inhibitors of β and γ-secretases in silico, showing better binding and pharmacokinetic properties than galantamine.
Journal of Alzheimer s Disease · Feb 1, 2025Peer-reviewedBioinformatics