BioinformaticsbioRxivPreprint
SoftHybrid: A Hybrid Imputation Algorithm Optimised for Single-Cell Proteomics Data
Yixin Shi, Simon J. Davis, Philip D. Charles…·Roman Fischer
SoftHybrid improves single-cell proteomics data imputation by jointly modeling missingness and protein abundance, outperforming existing methods at low input and matching them at the mini-bulk level.
DOI 10.64898/2026.01.13.699212