Simon J. Davis

This paper develops a spatial pharmacology workflow using LCM-LC-PRM to profile MMAE distribution in tumour and healthy tissues, revealing heterogeneous and time-dependent accumulation patterns.

The paper develops a spatial tri-omics workflow to map genetically distinct myeloma subclones in bone marrow, showing they occupy spatially and biologically distinct niches.

This paper introduces a new spectral single-molecule microscopy technique using spatially patterned detectors, achieving spectral and positional resolution without complex optical components.

This paper introduces ARMS DNAseq, a scalable spatial genomic assay that maps copy number subclones in archival tissue, revealing tumor evolution and subclone associations with morphology and transcriptomic features.

SoftHybrid improves single-cell proteomics data imputation by jointly modeling missingness and protein abundance, outperforming existing methods at low input and matching them at the mini-bulk level.

This study maps the NFκB pathway in T-cells using CRISPR screens and identifies novel regulators that enhance cytotoxicity and cytokine production.

This study shows that hyaluronidase improves CEACAM5 accessibility on colorectal cancer cells, enhancing CAR T-cell therapy effectiveness by reducing glycocalyx thickness and restoring sustained T-cell activation.

The paper shows that T-cell activation is initiated by partial CD45 exclusion at sub-micron contacts, leading to strong activation and cytotoxicity through small signaling changes.

The antigen sensitivity of CAR-T cells can be tuned to match the sensitivity of TCR-T cells by varying the relative extracellular size of CAR/antigen and CD2/CD58 complexes.

The paper uses bulk RNA-seq and single-cell RNA-seq data to study T-cell expansion and identifies FOSL1 as a transcription factor that promotes an effector phenotype, enhancing cancer-cell killing.