Wenkang Wang

Accurate prediction of protein stability changes from single mutations using self-distillation and antisymmetric constraint strategies

DPStab predicts protein stability changes from single mutations using self-distillation and antisymmetric constraints, achieving state-of-the-art performance in ΔΔG and ΔTm prediction.

Unified modeling of mutation-induced protein stability responses with OmegaTherm

OmegaTherm predicts mutation-induced protein stability responses by jointly modeling folding free energy and melting temperature, achieving state-of-the-art performance in prediction and variant ranking.