Biochemical evidence of furin specificity and potential for phospho-regulation at Spike protein S1/S2 cleavage site in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV
Mihkel Örd, Ilona Faustova, Mart Loog
The paper identifies a furin cleavage motif in SARS-CoV2 Spike protein that requires a specific RRxR motif for cleavage and shows that phosphorylation of adjacent serines inhibits furin activity.
Scientific Reports · Oct 9, 2020Peer-reviewedMolecular Biology