Novel antibiotic mode of action by repression of promoter isomerisation
Leena Kerr, Douglas F. Browning, Kimon Lemonidis, Talal S. Salih, Iain S. Hunter, Colin J. Suckling, Nicholas P. Tucker
This paper identifies MGB-BP-3 as an antibiotic that inhibits promoter isomerisation in S. aureus, showing resistance evolution is unlikely.
bioRxiv · Dec 31, 2020 · PreprintMolecular Biology