The paper reports genome sequences of ten multidrug-resistant Escherichia coli strains from Egyptian children with diarrhoea, identifying resistance genes and high-risk clones.

DOI 10.1101/2025.10.02.680073

E. coliwhole-genome sequencing

𝕏 PostBluesky

MicrobiologybioRxivPreprintMay 9, 2025

Genome-wide mapping of cyclic AMP receptor protein binding in Enteroaggregative Escherichia coli reveals targeting of virulence-associated genes

Munirah M. Alhammadi, Joanne Hothersall, Georgina S. Lloyd…·James R. J. Haycocks

This study maps CRP binding sites in EAEC to reveal its role in regulating virulence genes linked to nutritional state.

DOI 10.1101/2025.05.09.652842

E. coliChIP-seq

𝕏 PostBluesky

GenomicsbioRxivPreprintJun 29, 2022

Laboratory strains of Escherichia coli K-12: not such perfect role models after all.

Douglas F. Browning, Jon L. Hobman, Stephen J. W. Busby

The paper sequences two ancestral E. coli K-12 strains to reveal genetic changes from lab-based evolution, questioning their suitability as model organisms.

DOI 10.1101/2022.06.29.497745

E. coliwhole-genome sequencing

𝕏 PostBluesky

Molecular BiologybioRxivPreprintDec 31, 2020

Novel antibiotic mode of action by repression of promoter isomerisation

Leena Kerr, Douglas F. Browning, Kimon Lemonidis…·Nicholas P. Tucker

This paper identifies MGB-BP-3 as an antibiotic that inhibits promoter isomerisation in S. aureus, showing resistance evolution is unlikely.

9 citations

humanbulk RNA-seq

𝕏 PostBluesky