Matthias Misslinger

Cooperative cluster-binding regulates the functional transitions of the Aspergillus fumigatus iron regulator HapX for adaptation to iron starvation, sufficiency and excess

This study shows that HapX, an iron regulator in Aspergillus fumigatus, transitions between states based on iron availability through cluster-binding in conserved cysteine-rich regions, affecting gene expression and iron homeostasis.