This study identifies genetic variants associated with healthcare costs across multiple systems, finding polygenic influences and large effects from specific loss-of-function variants.

medRxiv · Jul 15, 2026 · PreprintGenetic & Genomic Medicine

Population-scale inheritance analysis of 858,635 individuals reveals North Sea migration from the Middle Ages to the Industrial Revolution

Xiaolei Zhang, Poul Holm, Aylwyn Scally, Karina Banasik, Laust Hvas Mortensen, Tomas W. Fitzgerald, David Westergaard, Piotr Jaroslaw Chmura, Sisse Rye Ostrowski, Erik Sørensen, Ole Birger Pedersen, Michael Schwinn, Christian Erikstrup, Mie Topholm Bruun, Bitten Aagaard Jensen, , Ewan Birney

The paper uses genetic data from Denmark and Britain to infer historical North Sea migrations from the Middle Ages to the Industrial Revolution, identifying distinct population patterns and migration trends.

bioRxiv · Mar 19, 2025 · PreprintGenetics

Uncovering the Heritable Components of Multimorbidities and Disease Trajectories: A Nationwide Cohort Study

David Westergaard, Frederik Hytting Jørgensen, Jens Waaben, Mette Lademann, Thomas Folkmann Hansen, Jolien Cremers, Sisse Rye Ostrowski, Ole Birger Pedersen, Roc Requant, Isabella Friis Jørgensen, Tomas W. Fitzgerald, Ewan Birney, Karina Banasik, Laust Hvas Mortensen, Søren Brunak

This study uses Danish registries to estimate heritability and genetic correlations of disease phenotypes and trajectories, identifying novel genetic associations and sex-specific contributions.

medRxiv · Feb 8, 2023 · PreprintGenetic & Genomic Medicine