Julien Diharce

This study uses molecular dynamics simulations to compare the effects of N-glycosylation on IgG2 and IgG4 antibodies, showing subclass-dependent impacts on flexibility and antigen binding.

PATHOS predicts variant pathogenicity by integrating protein language models and biological features, achieving high accuracy on clinical and ClinVar datasets.

This study evaluates 65 variant effect predictors, finding AlphaMissense performs best and variants are classified as easy, moderate, or hard to predict based on structural and functional information.