Dual agonism of sodium iodide symporter function in vivo
Katie Brookes, Caitlin E.M. Thornton, Ling Zha, Jana Kim, Benjamin Small, Selvambigai Manivannan, Hannah R. Nieto, Holly V. Adcock, Giovanni Bottegoni, Liam R. Cox, Vinodh Kannappan, Weiguang Wang, Caroline M. Gorvin, Sissy Meihua Jhiang, Matthew David Ringel, , Christopher J. McCabe
This study identifies Cu(DDC)2-alb as a dual agonist that enhances RAI uptake in thyroid cancer by stabilizing NIS and inducing thyroid transcription factors.
bioRxiv · Feb 27, 2024 · PreprintCancer Biology