Matthew David Ringel

This paper develops a metastasis-on-a-chip model to study thyroid cancer to lung metastasis, showing that RCAN1.4 suppression enhances metastasis and that NK-92 cells reduce metastases.

The paper examines the mutual exclusivity and clinical associations of germline long-telomere syndrome variants and somatic TERT promoter mutations in thyroid cancer and melanoma, finding they are mutually exclusive but have distinct clinical impacts.

This paper introduces mLumiOpto, a mitochondrial-targeted gene therapy that disrupts cancer cell mitochondria using light-activated proteins, showing efficacy in reducing tumor burden in mouse models.

This study identifies Cu(DDC)2-alb as a dual agonist that enhances RAI uptake in thyroid cancer by stabilizing NIS and inducing thyroid transcription factors.