Giovanni Bottegoni

This study investigates how the redox state of an iron-sulfur cluster in APSR from Pseudomonas aeruginosa influences catalytic activity and substrate binding through molecular simulations.

This study investigates how a specific mutation in the ASNS gene impairs enzyme function by disrupting conformational dynamics, using biochemical, cryo-EM, and molecular dynamics approaches.

This study identifies Cu(DDC)2-alb as a dual agonist that enhances RAI uptake in thyroid cancer by stabilizing NIS and inducing thyroid transcription factors.