Hyperosmotic stress induces downstream-of-gene transcription and alters the RNA Polymerase II interactome despite widespread transcriptional repression
Nicolle A. Rosa-Mercado, Joshua T. Zimmer, Maria Apostolidi, Jesse Rinehart, Matthew D. Simon, JOAN ARGETSINGER STEITZ
The paper shows hyperosmotic stress causes transcriptional repression but still leads to downstream-of-gene (DoG) transcripts, with Pol II interactome changes and Integrator complex disruption involved.
Molecular Cell · Jan 9, 2021Peer-reviewedMolecular Biology