Low-Coverage Genome Sequencing Outperforms Target Enrichment Phylogenomics
Michael G. Branstetter, Felipe V. Freitas, Ligia R. Benavides, Silas Bossert, Bryan N. Danforth, Elizabeth A. Murray
This study compares low-coverage whole genome sequencing (lcWGS) and target enrichment methods for phylogenomics, finding lcWGS outperforms target enrichment in locus recovery and phylogenetic performance, especially with degraded DNA.
bioRxiv · Jun 9, 2026 · PreprintEvolutionary Biology