Lucas de Almeida Machado

A novel benchmark dataset for enzyme function prediction reveals the limitations of state-of-the-art models

This paper introduces a benchmark dataset for enzyme function prediction and shows that current models struggle to distinguish non-functional enzyme variants from functional ones.

A Genetic Algorithm to scour protein sequence space: A novel framework for protein engineering using protein language models and force fields

GAPO uses genetic algorithms with protein language models and force fields to optimize protein sequences, outperforming simulated annealing in binding and stability.