Author

Luezhen Yuan

Broad InstituteORCID 0000-0002-6575-9339Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

G. V. ShivashankariD· 2 shared Hui Liu· 2 shared Caroline UhleriD· 1 shared Fei CheniD· 1 shared Lucrezia BaldiiD· 1 shared Orr AshenbergiD· 1 shared Qitian WuiD· 1 shared Qiyu Gong· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

G. V. ShivashankarORCID

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3 papers

Recent·Most cited

Multi-modal foundation model with whole-slide attention enables transferrable digital pathology at single-cell resolution

Qitian Wu, Qiyu Gong, Luezhen Yuan, Zhiyi Li, Orr Ashenberg, Fei Chen, Ramnik J. Xavier, Caroline Uhler

TissueFormer is a foundation model that predicts spatial gene expression from histology images at single-cell resolution and scales to diagnostic tasks.

bioRxiv · Aug 6, 2026 · PreprintBioinformatics

Identifying regulators of aged fibroblast activation in 3D tissue models

Hui Liu, Luezhen Yuan, G. V. Shivashankar

This study identifies three master regulators of aged fibroblast activation using 3D tissue models and pharmacological inhibitors.

Scientific Reports · Nov 26, 2025Peer-reviewedCell Biology

Compressive forces induce epigenetic activation of aged human dermal fibroblasts through ERK signalling pathway

Hui Liu, Luezhen Yuan, Lucrezia Baldi, Trinadha Rao Sornapudi, G. V. Shivashankar

This study shows compressive forces rejuvenate aged human dermal fibroblasts via ERK signaling, inducing epigenetic changes and increased collagen I.

Aging Cell · Mar 13, 2025Peer-reviewedCell Biology