Multi-modal Graph Integration for Biologically Interpretable Domain Identification Using Spatial Transcriptomics
S.J. Lee, Guolun Wang, Kyungtae Kang, Jichao Chen, Mingon Kang
This study introduces BIGraph-ST, a method that integrates pathway activity and histological features to improve spatial domain identification in spatial transcriptomics, showing better performance in cancer tissues.
bioRxiv · Aug 5, 2026 · PreprintBioinformatics