Thomas B. L. Kirkwood

Inferring Accumulation Times of Mitochondrial DNA Deletion Mutants from Cross-Sectional Single-Cell Data: Methodological Framework and Validation

This paper develops a method to infer mtDNA deletion mutant accumulation times from scRNA-seq data using a Moran process model, validated on synthetic datasets.

Inferring Accumulation Times of Mitochondrial DNA Deletion Mutants from Cross-Sectional Single-Cell Data: Application to Tabula Muris Senis

The paper infers mtDNA deletion accumulation times from scRNAseq data in mouse muscle cells, finding mean accumulation times of ~3 months.

Tentative evidence that aging is caused by a small number of interacting processes

The paper analyzes survival data from mice studies to show that aging is driven by a small number of interacting processes, not independent damage accumulation, and suggests this could extend human lifespan.