Axel Kowald

This paper develops a method to infer mtDNA deletion mutant accumulation times from scRNA-seq data using a Moran process model, validated on synthetic datasets.

The paper infers mtDNA deletion accumulation times from scRNAseq data in mouse muscle cells, finding mean accumulation times of ~3 months.

The paper analyzes survival data from mice studies to show that aging is driven by a small number of interacting processes, not independent damage accumulation, and suggests this could extend human lifespan.

The paper describes a method using pathway maps to analyze omics data, focusing on cellular senescence and its role in disease.