Systems BiologyiSciencePeer-reviewed
Transcriptional noise sets fundamental limits to decoding circadian clock phase from single-cell RNA snapshots
Anjoom Nikhat, Taniya Mandal, Nivedha Veerasubramanian, Shaon Chakrabarti
This study shows that transcriptional noise limits single-cell phase inference of circadian clocks, but averaging RNA levels across cells can enable accurate phase detection.