PhysiologyRedox BiologyPeer-reviewed
A hypothalamus-liver-skeletal muscle axis controlled by JNK1 and FGF21 mediates olanzapine-induced insulin resistance in an intraperitoneal treatment in male mice
Vítor Ferreira, Cintia Folgueira, Ana B. Hitos…·Ángela M. Valverde
This study shows that intraperitoneal olanzapine treatment in male mice causes insulin resistance via a hypothalamus-liver-skeletal muscle axis involving JNK1 and FGF21, with PTP1B deficiency offering protection.
DOI 10.1016/j.redox.2026.104286