Inhibition of cAMP signaling prevents congenital heart defects counteracting oxidative stress in Pde2A deficient embryos
Silvia Cardarelli, Martina Biglietto, Tiziana Orsini, Valentina Fustaino, Lucia Monaco, Ana Gabriela de Oliveira doRego, Francesca Liccardo, Silvia Masciarelli, Francesco Fazi, Fabio Naro, Luciana De Angelis, Manuela Pellegrini
This study identifies molecular mechanisms and drug targets for congenital heart defects in Pde2A-deficient embryos by analyzing gene expression and testing cAMP and oxidative stress modulators.
bioRxiv · May 29, 2023 · PreprintDevelopmental Biology