Author

Manuela Pellegrini

National Research CouncilORCID 0000-0001-6387-5187Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Animal Behavior & Cognition· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:electrophysiology· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Fabio NaroiD· 2 shared Silvia CardarelliiD· 2 shared Alessandra TempioiD· 1 shared Ana Gabriela de Oliveira doRego· 1 shared Andrei TurtoïiD· 1 shared Asma Boulksibat· 1 shared Barbara BardoniiD· 1 shared Carole RovèreiD· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersDevelopmental Biology

Fabio NaroORCID

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3 papers

Recent·Most cited

Animal Behavior & CognitionNeurobiology of DiseasePeer-reviewedDec 26, 2023

Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of Phosphodiesterase 2A

Sébastien Delhaye, Marielle Jarjat, Asma Boulksibat…·Barbara Bardoni

This study investigates the role of PDE2A in socio-cognitive deficits by analyzing Pde2a+/- mice, revealing microglia activation and AMPAR trafficking defects linked to cognitive impairments.

11 citations

mouseelectrophysiology

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Developmental BiologybioRxivPreprintMay 29, 2023

Inhibition of cAMP signaling prevents congenital heart defects counteracting oxidative stress in Pde2A deficient embryos

Silvia Cardarelli, Martina Biglietto, Tiziana Orsini…·Manuela Pellegrini

This study identifies molecular mechanisms and drug targets for congenital heart defects in Pde2A-deficient embryos by analyzing gene expression and testing cAMP and oxidative stress modulators.

DOI 10.1101/2023.05.29.542779

mousebulk RNA-seq

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Developmental BiologybioRxivPreprintJan 18, 2023

The phosphodiesterase 2A regulates lymphatic endothelial development via cGMP-mediated control of Notch signaling

Claudia Carlantoni, Leon M.H. Liekfeld, Sandra A. Hemkemeyer…·Maike Frye

This study identifies PDE2A as a regulator of lymphatic endothelial development through cGMP-mediated control of Notch signaling, showing its role in junction maturation and cell cycle arrest.

DOI 10.1101/2023.01.18.524585

mousehuman

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