Spatial Transcriptomics Reveals CXCL12+ Fibroblasts as Central Immune Organizers through CXCR4 Signaling in Abdominal Aortic Aneurysm
Dina Lévy-Lambert, Joel L. Ramirez, Saba Shaikh, Cesar De Jeronimo Diaz, April G. Huang, Alexis J. Combes, Gabriela K. Fragiadakis, Trevor P. Fidler, Adam Oskowitz
This study uses spatial transcriptomics to identify CXCL12+ fibroblasts as central immune organizers in AAA through CXCR4 signaling, revealing stromal-immune interactions that drive disease progression.
bioRxiv · Nov 24, 2025 · PreprintCell Biology