Trevor P. Fidler

Macrophage EHD1 promotes inflammation and stabilizes sortilin to accelerate atherosclerosis

This study shows EHD1 promotes inflammation and stabilizes sortilin in macrophages, accelerating atherosclerosis through enhanced TNFR2-NF-kB signaling and endocytic recycling.

Aggressive Cholesterol Lowering Normalizes Atherosclerosis Regression in Jak2V617F Mice

This study shows that aggressive cholesterol lowering halts atherosclerosis progression and promotes plaque stabilization in Jak2V617F mice by reversing inflammasome activation and increasing pro-resolving macrophage features.

Spatial Transcriptomics Reveals CXCL12+ Fibroblasts as Central Immune Organizers through CXCR4 Signaling in Abdominal Aortic Aneurysm

This study uses spatial transcriptomics to identify CXCL12+ fibroblasts as central immune organizers in AAA through CXCR4 signaling, revealing stromal-immune interactions that drive disease progression.

IL-18 inhibition enlarges lesions, necrotic cores and thickens fibrous caps in Jak2V617F clonal hematopoiesis-driven atherosclerosis.

This study shows that IL-18 inhibition increases atherosclerosis lesions and necrotic cores in Jak2V617F clonal hematopoiesis mice, despite improving fibrous cap thickness.

Macrophages redeploy functional cancer cell surface proteins following phagocytosis

This study shows that macrophages transfer intact cancer cell surface proteins to their own surface after phagocytosis, which may affect their function and metabolism.

Genetic modification of inflammation and clonal hematopoiesis-associated cardiovascular risk

The paper identifies IL1RAP and AIM2 as key modifiers of CHIP-associated cardiovascular risk using UK Biobank data and CRISPR experiments in mice.