The paper generates a single-cell DNA methylome and 3D multi-omic atlas of the adult mouse brain, identifying methylation patterns and regulatory networks across cell types and brain regions.

Nature · Dec 13, 2023Peer-reviewedGenomics

An Atlas of Gene Regulatory Elements in Adult Mouse Cerebrum

Yang Eric Li, Sebastian Preißl, Xiaomeng Hou, Ziyang Zhang, Kai Zhang, Yunjiang Qiu, Olivier Poirion, Bin Li, Joshua Chiou, Hanqing Liu, António Pinto‐Duarte, Naoki Kubo, Xiaoyu Yang, Rongxin Fang, Xinxin Wang, , Bing Ren

The paper identifies 491,818 candidate cis regulatory elements in adult mouse brain sub-types and links them to target genes and transcriptional regulators involved in various pathways.

Nature · Oct 6, 2021Peer-reviewedNeuroscience

DNA Methylation Atlas of the Mouse Brain at Single-Cell Resolution

Hanqing Liu, Jingtian Zhou, Wei Tian, Chongyuan Luo, Anna Bartlett, Andrew I. Aldridge, Jacinta D. Lucero, Julia K. Osteen, Joseph R. Nery, Huaming Chen, Angeline C. Rivkin, Rosa Castanon, Ben Clock, Yang Eric Li, Xiaomeng Hou, , Joseph R. Ecker

The paper constructs a DNA methylation atlas of the mouse brain at single-cell resolution, revealing epigenetic diversity and spatial organization of neuronal subtypes.

Nature · Oct 6, 2021Peer-reviewedGenomics