Protein Synthesis Blockade Prevents Fear Memory Reactivation via Inhibition of Engram Synapse Strengthening
Ilgang Hong, Y. K. Kim, Hyunsu Jung, Chang‐Ho Kim, Jun-Hyeong Cho, Bong‐Kiun Kaang
This study shows that protein synthesis inhibition reduces engram synapse density and spine size, impairing fear memory recall and optogenetic reactivation in mice.
Proceedings of the National Academy of Sciences · Jan 12, 2026Peer-reviewedNeuroscience