Comparison of in silico predictions of action potential duration in response to inhibition of IKr and ICaL with new human ex vivo recordings
Yann-Stanislas H. M. Barral, Liudmila Polonchuk, Michael Clerx, David J. Gavaghan, Gary R. Mirams, Ken Wang
This paper compares in silico predictions of action potential duration changes with new human ex vivo recordings under IKr and ICaL inhibition, finding that no model accurately predicts all experimental outcomes.
bioRxiv · Feb 26, 2025 · PreprintPharmacology & Toxicology