Mouse models for V103I and I251L gain of function variants of the human MC4R display reduced adiposity and are not protected from a hypercaloric diet
Daniela Rojo, Clara Inés McCarthy, Jesica Raingo, Marcelo Rubinstein
This study introduces gain-of-function MC4R mutations into mice and finds they lead to leaner, shorter phenotypes and improved glucose homeostasis but do not protect against diet-induced obesity and diabetes.
Molecular Metabolism · Sep 9, 2020Peer-reviewedGenetics