Single point mutations can potentially enhance infectivity of SARS-CoV-2 revealed by in silico affinity maturation and SPR assay
Ting Xue, Weikun Wu, Ning Guo, Chengyong Wu, Jian Wen Huang, Lipeng Lai, Hong Liu, Yalun Li, Tianyuan Wang, Yuxi Wang
The paper predicts single point mutations in SARS-CoV-2 RBD that enhance binding affinity to hACE2 using in silico methods and validates them with SPR assays.
RSC Advances · Jan 1, 2021Peer-reviewedBioinformatics