Andrea Jorgensen

Evaluating the utility of amino acid similarity-aware kmers to represent TCR repertoires for classification

The paper evaluates kmer-based representations of TCR repertoires for classification, showing that reduced amino acid alphabets improve performance and interpretability in autoimmune disease classification.

Transcription factor binding and individual genetic risk for valproate teratogenicity

The paper investigates how genetic variants affecting transcription factor binding contribute to valproate-induced birth defects and identifies EP300 as a key regulator involved in this process.

APOE genotype and the effect of statins: a systematic review and meta-analysis.

This meta-analysis quantifies how APOE genotype affects statin response, showing greater reductions in LDL-C and similar effects on TC and TG in ε2 carriers, and smaller effects in ε4 carriers.

APOE Genotype and Statin Response: Evidence from Electronic Health Records in the UK Biobank and All of Us Research Program

This study examines the relationship between APOE genotype and statin response using electronic health records from UK Biobank and All of Us, finding significant associations with lipid levels and mortality risk.

APOE Genotype and Statin Response: Evidence from the UK Biobank Baseline Assessment and Linked Mortality Data

This study examines how APOE genotype interacts with statin use to affect lipid biomarkers and mortality using UK Biobank data, finding significant genotype-specific responses and increased mortality risk for APOE ε4ε4 carriers.

rareSurvival: rare variant association analysis for time-to-event outcomes.

The paper introduces rareSurvival, a software tool for analyzing rare variant associations with time-to-event outcomes, combining survival and gene-based methods.

Association of variants within the GST and other genes with anti-tubercular agents related toxicity: a systematic review and meta-analysis

This paper conducts a systematic review and meta-analysis to assess associations between genetic variants in GST and other genes and anti-tubercular drug-related toxicity, finding significant links for GSTM1 null and PXR rs3814057 polymorphisms.