Munir Pirmohamed

Genotype-predicted drug response phenotypes and their co-occurrence with dispensed medicines among 738,531 participants in the UK Our Future Health study

The paper assesses the co-occurrence of actionable pharmacogenomic phenotypes with dispensed medicines in 738,531 UK participants, finding 36.8% had gene-matched medications.

Clinically actionable pharmacogenomic landscape of antidepressants and antipsychotics in Qatar: A population-based cohort study

This study identifies actionable genetic variants in Qatar's population for antidepressants and antipsychotics, revealing high prevalence of metabolizer phenotypes impacting drug response.

APOE genotype and the effect of statins: a systematic review and meta-analysis.

This meta-analysis quantifies how APOE genotype affects statin response, showing greater reductions in LDL-C and similar effects on TC and TG in ε2 carriers, and smaller effects in ε4 carriers.

APOE Genotype and Statin Response: Evidence from Electronic Health Records in the UK Biobank and All of Us Research Program

This study examines the relationship between APOE genotype and statin response using electronic health records from UK Biobank and All of Us, finding significant associations with lipid levels and mortality risk.

APOE Genotype and Statin Response: Evidence from the UK Biobank Baseline Assessment and Linked Mortality Data

This study examines how APOE genotype interacts with statin use to affect lipid biomarkers and mortality using UK Biobank data, finding significant genotype-specific responses and increased mortality risk for APOE ε4ε4 carriers.