Author

Cecylia S. Lupala

Beijing Computational Science Research CenterORCID 0000-0002-6987-5230Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 2 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

Haiguang LiuiD· 3 shared Chun Fu WuiD· 1 shared Hong CheniD· 1 shared Vikash KumariD· 1 shared Xiao‐Dong SuiD· 1 shared Xiaodong SuiD· 1 shared Xuanxuan LiiD· 1 shared Xuefei LiiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBioinformatics

Haiguang LiuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Aromatic amino acids in the orthosteric region regulate cannabinoid receptor 1 conformation transitions

Cecylia S. Lupala, Xuanxuan Li, Xuefei Li, Haiguang Liu

This study investigates how aromatic amino acids in the orthosteric region of CB1 regulate conformational transitions using molecular dynamics simulations, revealing their roles in stabilizing active states and modulating receptor dynamics.

bioRxiv · Aug 18, 2025 · PreprintBiophysics

Mutations on RBD of SARS-CoV-2 Omicron variant result in stronger binding to human ACE2 receptor

Cecylia S. Lupala, Yongjin Ye, Hong Chen, Xiao‐Dong Su, Haiguang Liu

The paper models the structure of Omicron's RBD and human ACE2, showing mutations enhance binding strength through hydrogen bonding and increased buried surface area.

Biochemical and Biophysical Research Communications · Dec 24, 2021Peer-reviewedBioinformatics

Computational insights into differential interaction of mamalian ACE2 with the SARS-CoV-2 spike receptor binding domain

Cecylia S. Lupala, Vikash Kumar, Xiaodong Su, Chun Fu Wu, Haiguang Liu

The paper analyzes ACE2 sequences from 16 mammals and predicts ACE2-RBD complex structures to compare binding strengths across species.

bioRxiv · Feb 2, 2021 · PreprintBioinformatics