Xuefei Li

Aromatic amino acids in the orthosteric region regulate cannabinoid receptor 1 conformation transitions

This study investigates how aromatic amino acids in the orthosteric region of CB1 regulate conformational transitions using molecular dynamics simulations, revealing their roles in stabilizing active states and modulating receptor dynamics.

Navigated range expansion promotes migratory culling

The paper shows that increased bacterial motility during range expansion reduces phage spread by spatially sorting infected and uninfected cells, leading to migratory culling of viruses.

DeSide: A unified deep learning approach for cellular decomposition of bulk tumors based on limited scRNA-seq data

DeSide uses limited scRNA-seq data to estimate cell type proportions in bulk tumor samples, outperforming existing methods and enabling patient stratification based on survival rates.

Quantitative effects of co-culture on T cell motility and cancer-T cell interactions

This study investigates how co-culture affects T cell motility and cancer-T cell interactions, finding that specific T cells show increased contact time and directional persistence, while cancer cells develop distinct subpopulations with immunosuppressive and antigen-presenting properties.

Deep learning-based Spatial Feature Extraction for Prognostic Prediction of Hepatocellular Carcinoma from Pathological Images

This study develops a deep learning method to extract spatial features from H&E images of HCC, identifying features associated with patient survival and improving prognostic stratification when combined with clinical features.

Cross-regulation between proteome reallocation and metabolic flux redistribution governs bacterial growth transition kinetics

This study develops a computational framework to model how bacteria coordinate metabolic flux and proteome allocation during nutrient changes, revealing insights into growth transitions.