George Davey Smith

The paper assesses the transportability of mouse gene knockout models to human complex phenotypes using GPAT framework, finding evidence for 12 phenotypes but limited for others.

This paper shows that polygenic risk scores for CAD can create false treatment response patterns due to collider bias, not actual biological effects.

This study identifies genetic loci associated with childhood eating behaviour and shows they mediate obesity risk through distinct pathways, primarily driven by the child's own genotype.

This paper identifies shared genetic loci between inflammation and cancer risk using non-causal associations, revealing potential therapeutic targets.

This study identifies 20 genetic loci associated with knee alignment and shows genetic correlation with knee osteoarthritis, suggesting osteoarthritis may causally influence alignment.

The paper evaluates whether natural selection contributes to higher cardiometabolic disease risk in South Asians by analyzing genetic differentiation at disease-associated loci.

The paper identifies African-specific genetic loci associated with iron status and risk of severe malaria and bacteremia in children, highlighting limited transferability of European polygenic risk scores.

The paper introduces GPMap, a resource that maps genetic associations across traits and molecular measurements to identify pleiotropy and improve disease mechanism understanding.

This paper evaluates age-varying genetic effects on BMI and blood pressure traits using UK Biobank data, finding trait-dependent interactions that influence cardiovascular outcomes.

The paper evaluates the transportability of in-vitro gene perturbation models to in-vivo human phenotypes using CRISPR data and UK Biobank, finding some models are predictive while others are not.

This study investigates how DNA methylation (DNAm) links racial discrimination, economic adversity, and air pollution to health inequities using epigenome-wide association analyses.

This study identifies genetic and proteomic factors influencing pediatric stature across life stages and links them to adult height and type 2 diabetes risk.

This paper examines the feasibility of using Mendelian randomization to study the causal effects of childhood maltreatment on mental health, highlighting challenges in interpreting MR assumptions and results.

This study investigates causal links between T2D genetic clusters and non-cardiovascular comorbidities, identifying potential drug repurposing opportunities.

This study conducts GWAS on orofacial cleft subtypes, identifying 27 genome-wide significant regions, including novel loci, and highlights genetic heterogeneity and homogeneity across subtypes.

The paper identifies a novel genetic locus OSBPL11 associated with vitamin D levels and cardiometabolic health in African populations through genome-wide analysis.

This paper shows that genome-wide association studies on ratio traits can be misleading, as associations may be driven by the denominator rather than the numerator, and proposes a method to correct for collider bias.

The paper investigates the interaction between FADS2 genotype and breastfeeding on various traits in the UK Biobank and finds no evidence of such an interaction.

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

This study uses Mendelian randomization to identify two proteins, CCL27 and TNFRSF14, that influence subsequent cardiovascular events after a stroke, suggesting inflammation as a contributing factor.

This study investigates the genetic relationship between type 2 diabetes and schizophrenia, finding no strong causal link but identifying shared genomic loci and biological pathways.

The paper investigates historical coronavirus selection events using genetic data from China Kadoorie Biobank and UK Biobank, finding enrichment of virus-interacting genes in East Asians but not in UKB.

This study identifies genetic variants associated with alcohol flushing in East Asian populations and suggests self-reported flushing can be used as an instrumental variable for alcohol intake.

This paper uses Mendelian randomization and electronic health records to show SGLT2 inhibitors reduce prostate cancer risk, with additional evidence from differential expression analysis.

This study identifies genetic correlations and colocalizing signals between type 2 diabetes and osteoarthritis, highlighting shared pathways and effector genes.

This study uses GWAS and Mendelian randomization to show that lower sclerostin levels increase risk of hypertension, type 2 diabetes, myocardial infarction, and atherogenic lipid profiles.

This study uses Mendelian randomization to assess the causal effect of obesity and related metabolic traits on oral and oropharyngeal cancer risk, finding limited evidence of a direct causal link.

This study identifies 43 genomic loci associated with reproductive success in 785,604 individuals, showing ongoing natural selection at the FADS locus.

This study identifies genetic determinants of hip joint space width and finds they have opposing causal effects on hip osteoarthritis risk through distinct mechanisms.

This study evaluates polygenic risk score methods across diverse biobanks and ancestries, finding that European reference panels often yield better performance, while PRS-CS outperforms P+T for high-heritability traits.