Author

John D. Seigne

Dartmouth–Hitchcock Medical CenterORCID 0000-0002-7057-8727Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Approach:machine learning (classical)· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Bing Ren· 2 shared Brock C. ChristenseniD· 2 shared Chinaza F. NnamiD· 2 shared Elizabeth PflugradtiD· 2 shared Erick Alexander MboyaiD· 2 shared Fred KollingiD· 2 shared Jason R. PettusiD· 2 shared Li SongiD· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Bing Ren

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMay 31, 2026

Differential Transcript Usage Reveals Isoform-Level Remodeling of Tumor Biology in Clear Cell Renal Cell Carcinoma

Chinaza F. Nnam, Yiping Li, Minghui Zhang…·Lucas A. Salas

The paper identifies isoform-level changes in ccRCC using DTU analysis, revealing subgroups with distinct survival outcomes and potential biomarkers.

DOI 10.64898/2026.05.27.728189

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintMay 8, 2026

Retroelement Hypomethylation Links Hypoxia Signaling, Immune Phenotypes, and Survival in Clear Cell Renal Cell Carcinoma

Chinaza F. Nnam, Erick Alexander Mboya, Yiping Li…·Lucas A. Salas

This study identifies RE methylation subtypes in ccRCC linked to immune phenotypes and survival, validated across multiple cohorts.

DOI 10.64898/2026.05.01.722263

humanDNA methylation

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BioinformaticsbioRxivPreprintDec 4, 2019

A Machine Learning Approach for Long-Term Prognosis of Bladder Cancer based on Clinical and Molecular Features

Qingyuan Song, John D. Seigne, Alan R. Schned…·Saeed Hassanpour

This study develops a machine learning model to predict 10-year overall survival in bladder cancer patients using clinical and molecular features, without relying on tumor grade classification.

16 citations

humanbulk RNA-seq

𝕏 PostBluesky