This study identifies genetic and proteomic factors influencing pediatric stature across life stages and links them to adult height and type 2 diabetes risk.

medRxiv · Nov 10, 2025 · PreprintGenetic & Genomic Medicine

Characterization of the genetic architecture of BMI in infancy and early childhood reveals age-specific effects and implicates pathways involved in Mendelian obesity

Øyvind Helgeland, Marc Vaudel, Pol Solé-Navais, Christopher J. Flatley, Julius Juodakis, Jonas Bačelis, Ingvild L. Koløen, Gun Peggy Knudsen, Bente Berg Johansson, Per Minor Magnus, Ted Reichborn‐Kjennerud, Pétur Benedikt Júlíusson, Camilla Stoltenberg, Oddgeir L. Holmen, Ole A. Andreassen, , Stefan Johansson

This study identifies 46 BMI loci in children aged 0-8 years, revealing age-specific effects and pathways linked to Mendelian obesity.

Nature Metabolism · Mar 21, 2022Peer-reviewedGenetic & Genomic Medicine

Genome-wide association study reveals a dynamic role of common genetic variation in infant and early childhood growth

Øyvind Helgeland, Marc Vaudel, Pétur Benedikt Júlíusson, Oddgeir L. Holmen, Julius Juodakis, Jonas Bačelis, Bo Jacobsson, Haakon Lindekleiv, Kristian Hveem, Rolv Terje Lie, Gun Peggy Knudsen, Camilla Stoltenberg, Per Minor Magnus, Jørn Vegard Sagen, Anders Molven, , Pål R. Njølstad

This study identifies five BMI-associated loci across 12 time points in children, highlighting transient effects of common genetic variation in the leptin signaling pathway during infancy.

Nature Communications · Oct 1, 2019Peer-reviewedGenetics