The paper shows climate change drives lineage replacement in Phragmites australis through thermal tolerance, biomass, and asymmetric gene flow among polyploid lineages.

eLife · Sep 9, 2026Peer-reviewedEcology

Genetic canalization of nutrient resorption: evidence from a widespread grass under effective salt stress

L L Liu, Wenyi Sheng, Huijiaq Song, Cui Wang, Na Li, Lele Lin, Yaolin Guo, Ning DU, Weihua Guo

In 110 common-garden Phragmites australis genotypes, effective salt stress left N, P and K resorption efficiency largely unchanged; efficiency instead tracked phylogeographic lineage, ecotype and latitude.

bioRxiv · Aug 21, 2026 · PreprintEcology✦ In-depth digest

Single-cell and spatial transcriptomics uncover the role of B chromosomes in driving plant invasiveness

Cui Wang, James Ord, Mengxiao Yan, Yunfei Cai, Hongjin Shao, Lele Lin, Jarkko Salojärvi, Lele Liu, Weihua Guo

This study uses single-cell and spatial transcriptomics to identify B chromosome contributions to invasiveness in Phragmites australis.

Genome biology · Apr 22, 2026Peer-reviewedEvolutionary Biology

DeepMetabolism: A Deep Learning System To Predict Phenotype From Genome Sequencing

Weihua Guo, You (Eric) Xu, Xueyang Feng

DeepMetabolism predicts cell phenotypes from transcriptomics data with high accuracy, speed, and robustness using a biology-guided deep learning system.

bioRxiv · May 9, 2017 · PreprintSystems Biology

Data-Driven Prediction of CRISPR-Based Transcription Regulation for Programmable Control of Metabolic Flux

Jiayuan Sheng, Weihua Guo, Christine Ash, Brendan T. Freitas, Mitchell Paoletti, Xueyang Feng

The paper develops a data-driven model to predict CRISPR-based transcription regulation for programmable control of metabolic flux in yeast.

bioRxiv · Mar 22, 2017 · PreprintSynthetic Biology