Impact of integration on persistent homology clustering and biological signal detection in scRNA-seq data
Jonah C. Daneshmand, Julia H. Chariker, Akshitkumar M. Mistry, Eric Christian Rouchka
This paper evaluates how data integration affects persistent homology clustering and biological signal detection in scRNA-seq data, showing topological methods can help distinguish biological patterns from batch noise.
bioRxiv · Jul 24, 2025 · PreprintBioinformatics