Mechanisms of DNA repair have evolved to minimise the probability of nonsense mutations.
George Powell, Helen Long, Thomas M. M. Versluys, Ann‐Marie Mallon, Cecilia M. Lindgren, Michelle M. Simon
This study shows that DNA repair mechanisms in mice reduce the rate of nonsense mutations by prioritizing substitutions that are more deleterious to fitness.
bioRxiv · Jun 22, 2021 · PreprintGenomics