George Powell

The paper investigates the functional relationships of genes within TADs, finding that genes in CTCF-bound TADs are not more co-expressed or functionally similar than expected by proximity, but functionally important genes are more likely to occupy TADs alone.

This study shows that DNA repair mechanisms in mice reduce the rate of nonsense mutations by prioritizing substitutions that are more deleterious to fitness.

The paper estimates intraspecific constraint for mouse genes and shows strong correlation with human orthologues, linking constraint to pleiotropy and Mendelian disease.