Siddharth Deshpande

On the stabilization of plant lipid droplets: Dynamic interplay between oleosins and phospholipids

This study investigates the dynamic interaction between oleosins and phospholipids in stabilizing plant lipid droplets using microfluidic systems, revealing that oleosins primarily stabilize while phospholipids destabilize the interface.

Surface-stabilized sub-micron condensates for compartmentalizing synthetic cells and enhanced enzyme kinetics

This paper develops a method to create stable, size-controlled membraneless organelles using surfactant-like peptides and pH-responsive polypeptides, enhancing enzymatic reactions in synthetic cells.

pH-Responsive Phase Separation Dynamics of Intrinsically Disordered Peptides

This study investigates how pH affects phase separation dynamics of an intrinsically disordered glycine-rich protein from tick bioadhesive, revealing its impact on coacervation behavior and material properties.

Condensate-based shells and scaffolds via interfacial liquid-to-solid transition of disordered peptides

This paper demonstrates the self-assembly of a disordered peptide into stable shells and scaffolds through phase transitions at interfaces, with potential applications in biomedical engineering.

Regulating biocondensates within synthetic cells via segregative phase separation

This study demonstrates how segregative and associative phase separation interact within synthetic cell-like vesicles to create dynamic structures that regulate molecular distribution and membrane interactions.