Germline removal reprograms somatic genome maintenance towards faster, energy-efficient, high-fidelity DNA defence and repair
Jean‐Charles de Coriolis, Ghazal Alavioon, Wilfried Haerty, Emmanouil Tsakoumis, Monika Schmitz, Alice May Godden, Raheleh Rahbari, Alexei A. Maklakov, Simone Immler
This study shows that removing the germline in zebrafish reprograms somatic DNA repair and stress responses, favoring high-fidelity mechanisms and altering gene expression patterns across multiple organs.
bioRxiv · Sep 14, 2026 · PreprintGenetics