Covalent anti-HIV compound that induces HIV-1 capsid multimerization and degradation, decomposes the viral core
Tomofumi Nakamura, Nobutoki Takamune, Mayu Okumura, Jun‐ichirou Yasunaga, Masaharu Sugiura, Masayuki Amano
The paper describes a covalent anti-HIV compound, ACAi-001, that targets HIV-1 capsid to induce multimerization and degradation, offering a novel mechanism for HIV-1 inhibition.
bioRxiv · Apr 19, 2025 · PreprintMolecular Biology