Endothelial and non-endothelial responses to estrogen excess during development lead to vascular malformations
Silvia Parajes, Sophie Ramas, Didier Y. R. Stainier
This study shows that excess estrogen signaling during development causes vascular malformations in zebrafish by disrupting Hh/Vegf/Notch signaling and promoting aberrant endothelial cell behavior.
bioRxiv · May 11, 2018 · PreprintDevelopmental Biology