Didier Y. R. Stainier

This study uses real-time single-molecule imaging in zebrafish embryos to reveal non-canonical translation mechanisms of bmp2b mRNA.

This study identifies Junb as a regulator of inflammation during regeneration, showing that its loss leads to fibroinflammatory damage and impaired regeneration in zebrafish.

This study shows Vgll4 proteins regulate zebrafish organ size by both enhancing and limiting Yap1 activity in the posterior lateral line primordium.

This study shows that actomyosin organization in zebrafish cardiomyocytes drives cell shape changes during heart chamber curvature formation, influenced by both intrinsic and extrinsic factors.

This study identifies border-zone cardiomyocytes and macrophages as key contributors to ECM remodeling that facilitates cardiomyocyte invasion during zebrafish cardiac regeneration.

This study identifies Gpnmb as a critical regulator of immune and fibrotic responses during zebrafish heart regeneration, showing its role in macrophage function and ECM regulation.

This study shows that inactivating flt1 in zebrafish enhances cardiac regeneration by improving vascularization and reducing fibrosis.

This study identifies a genetic interaction between svep1 and tie1 in zebrafish lymphatic development, independent of Vegfc, and links it to human glaucoma.

This study shows that epicardial impairment in zebrafish leads to smaller ventricles due to defective cardiomyocyte growth, highlighting the role of FGF and VEGF signaling in cardiac morphogenesis.

This study identifies a missense mutation in the furinb gene in zebrafish that causes hepatic cysts by disrupting ER homeostasis and mTOR signaling during liver development.

The paper identifies fibroblast-like cell types as key drivers of heart regeneration in zebrafish using single-cell transcriptomics and lineage tracing.

This study shows that Gpr126 regulates Notch activity and N-cadherin localization to establish trabecular identity in zebrafish cardiomyocytes.

The paper identifies TRAP+ osteolytic tubules as critical for defining fin ray branchpoints through bone resorption and mineralization balance.

This study identifies Svep1 as a factor that stabilizes vascular anastomosis in zebrafish embryos under reduced flow conditions.

This study shows that Apelin signaling-dependent endocardial protrusions are essential for cardiac trabeculation by modulating cardiomyocyte behavior through Neuregulin and Erk signaling.

This study identifies an autocrine role for Hedgehog signaling in regulating epithelial cell proliferation and differentiation in the trachea.

This study shows that mesodermal cells can differentiate into insulin-producing β-cells without endothelial specification, revealing a new pathway for β-cell regeneration in zebrafish.

The paper shows that Pdgfrb signaling is essential for mural cell development in zebrafish, similar to mice, and identifies context-dependent roles in vascular structures.

This study identifies Snai1's role in maintaining myocardial wall integrity by repressing intermediate filament gene expression in zebrafish.

This study shows that endothelial TGF-β signaling is crucial for cardiac outflow tract development, as its disruption leads to OFT dilation and SMC disorganization, which can be partially rescued by fibulin-5 modulation.

The paper uses sci-ATAC-seq and a new tool, ScregSeg, to analyze chromatin dynamics in zebrafish embryos, revealing roles of npas4l/cloche in cell and regulatory states.

The paper combines multiple imaging techniques to detect cardiac defects in adult zebrafish that were previously undetectable.

The paper shows that cardiac function affects endocardial cell dynamics, which in turn shape the cardiac outflow tract in zebrafish.

This study shows adult zebrafish can regenerate cardiac valves after decellularization, with TGF-β signaling promoting this process by enhancing progenitor cell proliferation and differentiation.

This study identifies Hhex as a regulator of hepatopancreatic ductal system specification and growth in zebrafish, showing its role in progenitor specification and interaction with blood vessels and the yolk syncytial layer.

This study identifies interferon-stimulated gene and cellular stress pathway activation in zebrafish morpholino-injected embryos, suggesting morpholinos may trigger innate immune responses.

This study investigates the role of Crb2a in zebrafish cardiac development, showing it regulates cell-cell adhesion and apicobasal polarity during trabeculation.

The paper shows that mutant mRNA degradation triggers transcriptional adaptation in zebrafish and mouse, leading to upregulation of related genes.

The paper identifies Npas4l target genes involved in cardiovascular development using zebrafish models and genome-wide approaches.

The paper identifies insulin-independent modulators of glucose metabolism using a zebrafish model and finds androgen receptor antagonists reduce fasting glucose levels in insulin mutants.