Cancer BiologyCancer Immunology ImmunotherapyPeer-reviewed
Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK-3 activation and PD-1 expression
Tommaso Montecchi, Giulia Nannini, Domiziana De Tommaso…·Cristina Ulivieri
This study identifies Rai as a novel HIF-1-responsive gene upregulated in CRC TILs, which promotes T cell exhaustion by sustaining GSK-3 activation and PD-1 expression.
7 citations